Nerve development

Across TCGA patient cohorts, RNA activity of the Nerve development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPPP, CAMK2A, and CXorf38, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nerve development activity versus TPPP in GBM (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPPP →	+1.500	+0.641	<.001	<.001	3	4
GBM	CAMK2A →	+1.438	+0.644	<.001	<.001	3	4
GBM	CXorf38 →	-0.297	-0.579	.004	.004	3	4
GBM	KIAA0513 →	+0.935	+0.526	<.001	<.001	3	3
CCRCC	RBP4 →	+2.046	+0.830	<.001	<.001	3	3
CCRCC	ARMH4 →	+0.567	+0.868	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021675 vs TPPP — GBM

Explore this scatter interactively →