Lateral ventricle development

Across TCGA cell cohorts, RNA activity of the Lateral ventricle development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASF1, PLEKHM3, and KLHDC10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WASF1 grouped by Lateral ventricle development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	WASF1 →	-1.912	-1.615	.006	.001	3	5
PANCREAS	PLEKHM3 →	-0.468	-1.036	.009	.008	3	5
LUNG_NSCLC_LUAD	KLHDC10 →	-0.596	-0.758	<.001	.007	3	4
PANCREAS	NAB2 →	-1.691	-1.718	<.001	<.001	3	4
PANCREAS	MTF2 →	-0.546	-0.992	.004	.007	3	4
STOMACH	PLEKHN1 →	+1.024	+0.907	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WASF1 by Lateral ventricle development activity — BONE

Explore this box plot interactively →