Facial nerve structural organization

Across TCGA patient cohorts, RNA activity of the Facial nerve structural organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSHZ3, SH3RF3-AS1, and CDH11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Facial nerve structural organization activity versus TSHZ3 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSHZ3 →	+0.852	+0.862	.003	<.001	3	4
UCEC	SH3RF3-AS1 →	+0.688	+0.662	.007	.005	3	4
LUAD	CDH11 →	+0.619	+0.594	<.001	<.001	3	4
UCEC	SYDE1 →	+0.652	+0.648	.001	.004	3	3
PDAC	AEBP1 →	+0.656	+0.534	.001	.002	3	3
PDAC	PALLD →	+0.445	+0.547	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021612 vs TSHZ3 — UCEC

Explore this scatter interactively →