Facial nerve structural organization

Across TCGA pan-cancer cohorts, RNA activity of the Facial nerve structural organization pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Facial nerve structural organization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

UCS, KIRC, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	All	0.868	0.494	.001	60	view →
KIRC	DFS	Quartile	III,IV	0.301	0.638	<.001	55	view →
COAD	OS	Tertile	All	0.409	0.697	<.001	53	view →
KIRP	DFS	Median	III,IV	0.173	0.860	<.001	50	view →
LGG	OS	Median	All	0.385	0.517	<.001	30	view →
HNSC	DFS	Quartile	III,IV	0.480	0.283	<.001	30	view →
LUSC	OS	Quartile	III,IV	0.064	0.811	<.001	23	view →
GBM	OS	Quartile	All	0.231	0.459	.002	21	view →
SKCM	OS	Tertile	III,IV	0.972	0.754	.011	16	view →
LAML	DFS	Median	All	0.347	0.555	.002	14	view →
LUAD	OS	Tertile	II,III,IV	0.588	0.341	.015	14	view →
TGCT	DFS	Median	II,III,IV	0.721	1.000	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0021612–UCS (OS)

Open the UCS breakdown →