Facial nerve structural organization

Across TCGA cell cohorts, RNA activity of the Facial nerve structural organization pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDF1, MTBP, and LRRC39, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDF1 grouped by Facial nerve structural organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EDF1 →	+0.221	+0.189	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MTBP →	-0.221	-0.265	<.001	.001	3	4
LIVER	LRRC39 →	-0.438	-0.254	.004	.007	3	4
OESOPHAGUS	TAF4 →	-0.424	-0.165	<.001	.001	3	4
KIDNEY	TGIF2-RAB5IF →	-0.217	-0.205	.001	.004	3	4
BLOOD_Leukemia	RAC3 →	-0.174	-0.773	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDF1 by Facial nerve structural organization activity — PANCREAS

Explore this box plot interactively →