Facial nerve morphogenesis

Across TCGA patient cohorts, RNA activity of the Facial nerve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8B, NRP1, and AEBP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Facial nerve morphogenesis activity versus C8B in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C8B →	+0.527	+0.076	<.001	<.001	3	9
OV	NRP1 →	+0.482	+0.093	.001	<.001	3	8
OV	AEBP1 →	+0.902	+0.100	<.001	.001	3	8
LSCC	AFAP1 →	+0.356	+0.048	<.001	<.001	3	8
LSCC	SERPINH1 →	+0.395	+0.067	<.001	<.001	3	8
OV	SFRP2 →	+1.369	+0.087	.006	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021610 vs C8B — LSCC

Explore this scatter interactively →