Facial nerve morphogenesis

Across TCGA cell cohorts, RNA activity of the Facial nerve morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTBP, LRRC39, and EDF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTBP grouped by Facial nerve morphogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTBP →	-0.221	-0.265	<.001	.001	3	4
LIVER	LRRC39 →	-0.438	-0.254	.004	.007	3	4
PANCREAS	EDF1 →	+0.221	+0.189	<.001	<.001	3	4
BLOOD_Leukemia	RAC3 →	-0.174	-0.773	.002	.005	3	4
KIDNEY	TGIF2-RAB5IF →	-0.217	-0.205	.001	.004	3	4
OESOPHAGUS	TAF4 →	-0.424	-0.165	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTBP by Facial nerve morphogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →