Cranial nerve structural organization

Across TCGA cell cohorts, RNA activity of the Cranial nerve structural organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSDMB, ATP9A, and DUOX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSDMB grouped by Cranial nerve structural organization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GSDMB →	+0.272	+0.380	.001	.006	3	4
BREAST	ATP9A →	-0.138	-0.142	<.001	.005	3	3
BLOOD_Myeloma	DUOX2 →	-0.365	-1.173	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	MTBP →	-0.221	-0.270	<.001	.001	3	3
BLOOD_Leukemia	MEN1 →	+0.223	+0.865	<.001	.002	2	4
BLOOD_Leukemia	NLRP3 →	-0.157	-1.159	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSDMB by Cranial nerve structural organization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →