Cranial nerve formation

Across TCGA cell cohorts, RNA activity of the Cranial nerve formation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1B, LRPAP1, and NECAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPT1B grouped by Cranial nerve formation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CPT1B →	+0.970	+0.730	.009	.001	3	4
LIVER	LRPAP1 →	+1.241	+1.041	.001	.003	3	4
SKIN	NECAP2 →	-0.404	-0.970	.002	.002	3	4
LUNG_NSCLC_LUAD	TGFB1 →	-2.165	-1.180	<.001	<.001	3	4
STOMACH	RPL36A →	-1.258	-1.383	.001	.005	3	4
OVARY	ZNF431 →	+1.275	+1.140	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPT1B by Cranial nerve formation activity — CNS

Explore this box plot interactively →