Glossopharyngeal nerve development

pathway activity — cross-omics
GO:0021563Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glossopharyngeal nerve development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16_S863, SLC35A1, and THBS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADIL16_S863 →-0.622-0.057.002.00435
PDACSLC35A1 →-0.491-0.037<.001.00234
PDACTHBS3 →+0.355+0.044.001<.00134
LUADARHGAP15_S64 →-0.537-0.050<.001.00434
UCECTFAM →+0.330+0.070<.001<.00134
OVC1QTNF6 →+1.479+0.087<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration