Vestibulocochlear nerve development

Across TCGA patient cohorts, RNA activity of the Vestibulocochlear nerve development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, COQ8A, and HTRA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve development activity versus TIMP2 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.549	+0.066	<.001	<.001	3	7
PDAC	COQ8A →	-0.366	-0.095	<.001	<.001	3	7
CCRCC	HTRA1 →	+0.711	+0.055	.006	<.001	3	7
BRCA	MAP4K5 →	+0.269	+0.096	<.001	<.001	3	7
HNSC	CD2 →	-0.609	-0.099	<.001	<.001	3	7
COAD	RHBDF1 →	+0.378	+0.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021562 vs TIMP2 — BRCA

Explore this scatter interactively →