Olfactory nerve development

Across TCGA patient cohorts, RNA activity of the Olfactory nerve development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD7, PTPN22, and AZGP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Olfactory nerve development activity versus CHD7 in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHD7 →	+0.697	+0.430	.002	.002	3	4
GBM	PTPN22 →	-0.463	-0.433	.006	.002	3	4
GBM	AZGP1 →	-1.465	-0.405	<.001	<.001	3	4
GBM	MIR635 →	-0.461	-0.425	<.001	.002	3	4
GBM	FAM214B →	-0.265	-0.397	.009	.006	3	4
UCEC	RBP2 →	-0.581	-0.210	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021553 vs CHD7 — BRCA

Explore this scatter interactively →