Olfactory nerve development

Across TCGA pan-cancer cohorts, RNA activity of the Olfactory nerve development pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Olfactory nerve development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and SCLC, show the opposite pattern, with higher activity associated with better survival.

KIRC, BRCA, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.426	0.624	<.001	107	view →
BRCA	OS	Quartile	II,III,IV	0.926	0.977	.001	57	view →
COAD	DFS	Quartile	III,IV	0.336	0.779	<.001	45	view →
LIHC	DFS	Quartile	II,III,IV	0.179	0.454	.003	38	view →
CESC	DFS	Tertile	All	0.763	0.906	.002	32	view →
UVM	DFS	Tertile	All	0.674	0.276	.017	32	view →
MESO	OS	Quartile	All	0.283	0.481	.013	27	view →
HNSC	DFS	Quartile	III,IV	0.505	0.705	.004	24	view →
SCLC	OS	Median	III,IV	0.601	0.306	.016	22	view →
LUAD	DFS	Quartile	All	0.730	0.850	.005	22	view →
KIRP	DFS	Quartile	IV	0.687	0.047	.017	17	view →
SARC	OS	Quartile	All	0.608	0.854	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0021553–KIRC (OS)

Open the KIRC breakdown →