Olfactory nerve development

Across TCGA cell cohorts, RNA activity of the Olfactory nerve development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNGB1, CHD7, and CD59, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNGB1 grouped by Olfactory nerve development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNGB1 →	-0.517	-0.571	<.001	.008	3	8
SOFT_TISSUE	CHD7 →	-0.577	-1.815	.001	.001	3	7
OVARY	CD59 →	+0.214	+0.567	<.001	.002	3	4
STOMACH	GRPEL1 →	-0.421	-0.338	.005	.001	3	3
PANCREAS	ARHGDIA →	-0.341	-0.449	.003	<.001	3	3
PANCREAS	CATSPER3 →	-0.208	-0.370	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNGB1 by Olfactory nerve development activity — LARGE_INTESTINE

Explore this box plot interactively →