Olfactory nerve development

Across TCGA cell cohorts, RNA activity of the Olfactory nerve development pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF175, AKAP17A, and ST8SIA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF175 grouped by Olfactory nerve development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNF175 →	+0.254	+0.230	.001	<.001	3	5
CNS	AKAP17A →	+0.154	+0.185	.002	.006	3	4
OESOPHAGUS	ST8SIA3 →	-0.165	-0.315	<.001	.002	3	4
BLOOD_Leukemia	FMC1-LUC7L2 →	+0.147	+0.836	.004	.006	3	4
LUNG_NSCLC_LUAD	SLC35D1 →	-0.078	-0.399	.007	.006	3	3
LUNG_NSCLC_LUSC	CDIPT →	+0.243	+0.422	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF175 by Olfactory nerve development activity — SOFT_TISSUE

Explore this box plot interactively →