Pons development

Across TCGA patient cohorts, RNA activity of the Pons development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZKSCAN1, CYBB, and FGR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pons development activity versus ZKSCAN1 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZKSCAN1 →	+0.282	+0.060	<.001	.002	3	7
GBM	CYBB →	-0.559	-0.105	<.001	<.001	3	7
GBM	FGR →	-0.664	-0.110	.001	<.001	3	7
GBM	ALOX5 →	-0.566	-0.103	<.001	<.001	3	7
GBM	HK3 →	-0.841	-0.103	<.001	<.001	3	7
GBM	ITGAM →	-0.722	-0.124	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021548 vs ZKSCAN1 — LSCC

Explore this scatter interactively →