Pons development

Across TCGA pan-cancer cohorts, RNA activity of the Pons development pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Pons development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.878	0.467	.002	54	view →
BRCA	OS	Quartile	II,III,IV	0.983	0.930	.001	42	view →
LUSC	OS	Median	All	0.808	0.717	.003	36	view →
UVM	DFS	Median	III,IV	0.268	0.798	.002	34	view →
LAML	DFS	Tertile	All	0.754	0.361	<.001	30	view →
LGG	DFS	Median	All	0.882	0.794	.001	26	view →
BLCA	OS	Quartile	II,III,IV	0.277	0.536	.003	25	view →
HNSC	DFS	Median	All	0.418	0.301	.007	15	view →
CESC	DFS	Quartile	III,IV	0.290	0.713	.040	12	view →
KICH	OS	Tertile	III,IV	0.526	1.000	.014	9	view →
DLBC	OS	Tertile	III,IV	0.209	0.797	.025	7	view →
SKCM	OS	Tertile	II,III,IV	0.229	0.357	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0021548–KIRP (OS)

Open the KIRP breakdown →