Pons development

Across TCGA patient cohorts, RNA activity of the Pons development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC11, SHARPIN, and ZNF696, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pons development activity versus HDAC11 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDAC11 →	+0.618	+0.567	<.001	<.001	3	5
BRCA	SHARPIN →	+0.711	+0.774	<.001	<.001	3	5
BRCA	ZNF696 →	+0.448	+0.665	<.001	<.001	3	5
BRCA	ZNF623 →	+0.528	+0.592	<.001	.003	3	5
HNSC	PCBD1 →	+0.598	+0.716	.007	<.001	3	4
BRCA	MINCR →	+0.839	+0.749	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021548 vs HDAC11 — BRCA

Explore this scatter interactively →