Subpallium development

Across TCGA patient cohorts, RNA activity of the Subpallium development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP5, TUBB6, and URM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subpallium development activity versus STXBP5 in OV (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STXBP5 →	+0.304	+0.047	<.001	<.001	3	5
OV	TUBB6 →	+0.482	+0.063	<.001	<.001	3	5
OV	URM1 →	+0.535	+0.050	.004	.001	3	5
OV	CD248_S746 →	+0.638	+0.049	<.001	<.001	3	5
OV	NCL →	-0.385	-0.034	<.001	.001	3	5
OV	PRKG1 →	+0.640	+0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021544 vs STXBP5 — OV

Explore this scatter interactively →