Subpallium development

Across TCGA patient cohorts, RNA activity of the Subpallium development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC14A, TIE1, and MYCT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subpallium development activity versus CLEC14A in CCRCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLEC14A →	+1.095	+0.406	<.001	<.001	3	8
CCRCC	TIE1 →	+0.886	+0.446	<.001	<.001	3	8
CCRCC	MYCT1 →	+0.931	+0.524	<.001	<.001	3	7
CCRCC	BCL6B →	+0.922	+0.425	<.001	<.001	3	7
CCRCC	TMEM88 →	+1.186	+0.521	<.001	<.001	3	7
CCRCC	RAMP2 →	+0.958	+0.461	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021544 vs CLEC14A — CCRCC

Explore this scatter interactively →