Subpallium development

Across TCGA cell cohorts, RNA activity of the Subpallium development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDCBP2, RPAIN, and TNFAIP8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDCBP2 grouped by Subpallium development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SDCBP2 →	-1.046	-0.763	.006	.006	3	3
OVARY	RPAIN →	+0.843	+0.791	.001	.008	3	3
OVARY	TNFAIP8 →	-1.774	-1.146	<.001	.004	3	3
OVARY	CDCP1 →	-2.462	-0.992	.001	.006	3	3
OVARY	HINT1 →	-0.704	-0.891	.001	.004	3	3
OVARY	RAB6C →	+0.067	+1.268	.008	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDCBP2 by Subpallium development activity — OVARY

Explore this box plot interactively →