Dentate gyrus development

Across TCGA patient cohorts, RNA activity of the Dentate gyrus development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS6KA4, MAGED2, and CASP10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dentate gyrus development activity versus RPS6KA4 in HNSC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS6KA4 →	-0.452	-0.084	<.001	<.001	3	6
LSCC	MAGED2 →	+0.418	+0.067	<.001	<.001	3	6
HNSC	CASP10 →	-0.435	-0.061	<.001	<.001	3	6
LSCC	ADNP →	+0.386	+0.081	<.001	<.001	3	6
LSCC	LYN →	-0.419	-0.052	<.001	<.001	3	6
GBM	NONO →	+0.166	+0.055	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021542 vs RPS6KA4 — HNSC

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