Dentate gyrus development

Across TCGA pan-cancer cohorts, RNA activity of the Dentate gyrus development pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Dentate gyrus development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and UCS, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.827	0.349	<.001	126	view →
KIRC	OS	Median	All	0.548	0.696	<.001	94	view →
UCS	OS	Median	IV	0.844	0.234	.005	90	view →
ACC	DFS	Median	All	0.401	0.740	<.001	88	view →
LIHC	DFS	Median	All	0.349	0.504	<.001	59	view →
SKCM	DFS	Median	All	0.686	0.572	<.001	46	view →
HNSC	OS	Median	II,III,IV	0.498	0.299	.009	32	view →
BRCA	OS	Tertile	III,IV	0.950	0.862	.007	32	view →
THYM	OS	Tertile	All	1.000	0.733	.005	22	view →
LGG	OS	Quartile	All	0.854	0.958	<.001	21	view →
SARC	OS	Quartile	All	0.579	0.803	<.001	19	view →
MESO	OS	Median	All	0.281	0.443	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0021542–UVM (OS)

Open the UVM breakdown →