Dentate gyrus development

Across TCGA patient cohorts, RNA activity of the Dentate gyrus development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD1, CCAR1, and HSD3BP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dentate gyrus development activity versus NEDD1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEDD1 →	+0.920	+0.905	<.001	<.001	3	4
LUAD	CCAR1 →	+0.180	+0.593	.006	.005	3	4
GBM	HSD3BP5 →	+0.550	+0.506	.004	.001	3	4
UCEC	MBTD1 →	+0.336	+0.970	.003	<.001	3	4
GBM	LANCL1 →	+0.573	+0.587	<.001	.003	3	4
UCEC	ILDR2 →	+0.903	+0.906	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021542 vs NEDD1 — BRCA

Explore this scatter interactively →