Dentate gyrus development

Across TCGA cell cohorts, RNA activity of the Dentate gyrus development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QPCT, TGFB3, and SERPINI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, QPCT grouped by Dentate gyrus development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	QPCT →	-3.996	-1.530	<.001	.002	3	4
BREAST	TGFB3 →	+2.131	+0.920	.002	.008	2	5
LIVER	SERPINI1 →	+2.149	+1.290	.004	.004	2	5
BLOOD_Myeloma	TM2D1 →	+0.811	+1.332	.005	.006	3	4
LARGE_INTESTINE	CLVS1 →	+0.078	+1.198	.009	<.001	3	4
BLOOD_Myeloma	ARFGEF1 →	+0.986	+1.433	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QPCT by Dentate gyrus development activity — LIVER

Explore this box plot interactively →