Dentate gyrus development

Across TCGA cell cohorts, RNA activity of the Dentate gyrus development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC61A2, TBC1D19, and CFL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dentate gyrus development activity versus SEC61A2 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEC61A2 →	+0.885	+1.107	<.001	<.001	3	6
STOMACH	TBC1D19 →	+1.436	+1.287	.002	.004	3	5
LARGE_INTESTINE	CFL2 →	+1.722	+0.736	.001	.004	3	5
LARGE_INTESTINE	FANCG →	+0.688	+0.754	<.001	.004	3	4
STOMACH	SGTB →	+1.371	+1.452	.002	.001	2	5
BLOOD_Lymphoma	CDK6 →	+1.914	+0.769	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021542 vs SEC61A2 — LARGE_INTESTINE

Explore this scatter interactively →