Corpus callosum morphogenesis

Across TCGA patient cohorts, RNA activity of the Corpus callosum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MALL, NOMO2, and LRRC3C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corpus callosum morphogenesis activity versus MALL in PDAC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MALL →	-0.685	-0.476	.001	.001	2	3
PDAC	NOMO2 →	+0.367	+0.409	<.001	.007	3	2
LSCC	LRRC3C →	-0.083	-0.158	.009	.006	3	2
OV	HNRNPA1P63 →	+0.232	+0.178	.008	.005	3	2
PDAC	H2AB1 →	-0.109	-0.327	.002	.004	3	2
OV	SPATA20 →	-0.544	-0.243	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021540 vs MALL — PDAC

Explore this scatter interactively →