Telencephalon development

Across TCGA patient cohorts, RNA activity of the Telencephalon development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, CNPY4, and PLOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telencephalon development activity versus THBS3 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THBS3 →	+0.510	+0.028	.002	.004	3	7
OV	CNPY4 →	+0.353	+0.025	<.001	.006	3	6
OV	PLOD1 →	+0.527	+0.032	.004	.002	3	6
GBM	SERPINB1 →	-0.502	-0.045	.001	<.001	3	6
HNSC	DBN1 →	+0.445	+0.044	<.001	.002	3	6
CCRCC	C1R →	+0.629	+0.023	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021537 vs THBS3 — UCEC

Explore this scatter interactively →