Telencephalon development

Across TCGA pan-cancer cohorts, RNA activity of the Telencephalon development pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 275 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Telencephalon development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, UCS, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.356	0.810	<.001	110	view →
UCS	DFS	Median	III,IV	0.653	0.219	<.001	104	view →
MESO	OS	Quartile	All	0.207	0.517	<.001	78	view →
KIRC	DFS	Median	All	0.551	0.678	<.001	68	view →
LIHC	OS	Median	All	0.693	0.838	<.001	50	view →
CESC	OS	Quartile	All	0.412	0.675	.009	48	view →
ESCA	OS	Tertile	III,IV	0.684	0.314	.002	29	view →
UCEC	DFS	Median	IV	0.918	0.539	.005	20	view →
HNSC	DFS	Quartile	IV	0.525	0.288	.005	15	view →
READ	OS	Tertile	III,IV	1.000	0.881	.022	11	view →
KICH	DFS	Quartile	All	0.694	1.000	.025	10	view →
SARC	OS	Median	All	0.493	0.670	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0021537–ACC (DFS)

Open the ACC breakdown →