Telencephalon development

Across TCGA patient cohorts, RNA activity of the Telencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGM5, NT5C1A, and HCRTR1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telencephalon development activity versus TGM5 in COAD (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TGM5 →	+0.046	+1.421	<.001	.001	3	1
COAD	NT5C1A →	+0.333	+1.831	<.001	<.001	3	1
COAD	HCRTR1 →	+0.105	+1.421	.002	.001	3	1
COAD	BMP15 →	+0.110	+1.804	<.001	<.001	3	1
COAD	SH3GL3 →	+0.040	+1.804	<.001	<.001	3	1
COAD	LRFN5 →	+0.489	+2.377	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021537 vs TGM5 — COAD

Explore this scatter interactively →