Telencephalon development

Across TCGA cell cohorts, RNA activity of the Telencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS19BP1, TERF2, and ETNK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS19BP1 grouped by Telencephalon development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RPS19BP1 →	+0.531	+0.181	<.001	<.001	3	5
LIVER	TERF2 →	+0.487	+0.164	.001	.006	3	4
STOMACH	ETNK1 →	+0.911	+0.196	.005	<.001	3	4
URINARY_TRACT	PSMC3 →	-1.184	-0.151	.004	.003	3	4
OESOPHAGUS	POC1B →	+0.949	+0.166	<.001	.007	3	4
SOFT_TISSUE	ANKRD33B →	-1.923	-0.168	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS19BP1 by Telencephalon development activity — BONE

Explore this box plot interactively →