Diencephalon development

Across TCGA patient cohorts, RNA activity of the Diencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY1, NR2F2, and TUBAP12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diencephalon development activity versus P2RY1 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P2RY1 →	+1.327	+0.700	<.001	<.001	3	5
GBM	NR2F2 →	+0.563	+0.393	.003	.004	3	4
GBM	TUBAP12 →	+0.576	+0.411	.003	.001	3	4
BRCA	CYBRD1 →	+1.292	+0.326	.001	.006	2	5
UCEC	PHLDB2 →	+0.811	+0.691	.004	.001	3	4
LSCC	KRT6B →	+2.472	+0.678	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021536 vs P2RY1 — LSCC

Explore this scatter interactively →