Diencephalon development

Across TCGA cell cohorts, RNA activity of the Diencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS8, C6orf132, and ERP27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diencephalon development activity versus PRSS8 in LUNG_NSCLC_LUSC (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRSS8 →	+3.892	+0.658	<.001	<.001	3	7
LUNG_NSCLC_LUSC	C6orf132 →	+3.434	+0.620	.008	.001	3	6
LUNG_NSCLC_LUAD	ERP27 →	+2.379	+0.276	<.001	<.001	3	6
STOMACH	LYPD3 →	+2.060	+0.382	.001	<.001	3	6
STOMACH	MDFI →	+2.203	+0.282	.004	.003	3	6
OVARY	VGLL1 →	+3.036	+0.343	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021536 vs PRSS8 — LUNG_NSCLC_LUSC

Explore this scatter interactively →