Cell migration in hindbrain

Across TCGA patient cohorts, RNA activity of the Cell migration in hindbrain pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATXN1, VIM, and CNN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell migration in hindbrain activity versus ATXN1 in OV (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ATXN1 →	+0.310	+0.058	<.001	<.001	3	7
UCEC	VIM →	+0.495	+0.071	<.001	<.001	3	6
PDAC	CNN3 →	+0.573	+0.060	<.001	<.001	3	6
OV	FHL3 →	+0.647	+0.052	<.001	<.001	3	6
OV	P3H3 →	+0.552	+0.047	<.001	<.001	3	6
LUAD	PDLIM4 →	+0.427	+0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021535 vs ATXN1 — OV

Explore this scatter interactively →