Cell migration in hindbrain

Across TCGA pan-cancer cohorts, RNA activity of the Cell migration in hindbrain pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Cell migration in hindbrain pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LUAD, show the opposite pattern, with higher activity associated with better survival.

CESC, HNSC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.209	0.680	.006	58	view →
HNSC	OS	Median	All	0.594	0.797	<.001	34	view →
LGG	OS	Median	All	0.855	0.933	<.001	33	view →
ESCA	OS	Median	IV	0.143	0.650	.004	24	view →
BLCA	DFS	Quartile	All	0.434	0.681	.016	15	view →
UVM	OS	Quartile	II,III,IV	0.781	0.415	.008	15	view →
BRCA	OS	Median	All	0.907	0.940	.010	14	view →
THCA	OS	Median	All	0.960	1.000	.011	11	view →
LUAD	OS	Median	All	0.436	0.321	.022	10	view →
PAAD	DFS	Median	II,III,IV	0.355	0.559	.010	9	view →
LUSC	OS	Quartile	All	0.785	0.661	.020	7	view →
LIHC	OS	Median	All	0.722	0.816	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0021535–CESC (DFS)

Open the CESC breakdown →