Cell migration in hindbrain

Across TCGA cell cohorts, RNA activity of the Cell migration in hindbrain pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM174C, CLMP, and ZNF529, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM174C grouped by Cell migration in hindbrain-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM174C →	+0.530	+0.787	.006	.003	3	4
LIVER	CLMP →	-2.636	-1.115	.008	.009	3	4
LUNG_NSCLC_LUSC	ZNF529 →	-0.910	-1.153	.002	<.001	3	4
STOMACH	TIGD2 →	+1.109	+1.348	.003	<.001	3	3
URINARY_TRACT	SMG9 →	-1.619	-1.769	.005	<.001	3	3
URINARY_TRACT	DOCK3 →	-2.203	-1.765	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM174C by Cell migration in hindbrain activity — BREAST

Explore this box plot interactively →