Cell proliferation in hindbrain

pathway activity — cross-omics
GO:0021534Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell proliferation in hindbrain pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBIAD1, LDAH, and TADA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAUBIAD1 →+0.375+0.728.001<.00136
LUADLDAH →+0.305+0.728.003<.00135
LUADTADA1 →+0.331+0.653.006.00135
BRCARBM33 →+0.403+0.866<.001<.00135
GBMMKS1 →+0.380+0.349<.001<.00135
BRCATTC31 →+0.374+0.669<.001.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration