Spinal cord association neuron differentiation

Across TCGA patient cohorts, RNA activity of the Spinal cord association neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAE1, SUDS3, and ZMYM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord association neuron differentiation activity versus SAE1 in BRCA (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAE1 →	+0.284	+0.136	<.001	<.001	3	5
BRCA	SUDS3 →	+0.240	+0.134	<.001	.001	3	5
BRCA	ZMYM2 →	+0.288	+0.116	<.001	.002	3	5
OV	BPTF →	+0.245	+0.188	.001	<.001	3	5
BRCA	FCHSD1 →	-0.328	-0.118	<.001	.001	2	6
BRCA	FLNC_S1527 →	-0.648	-0.137	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021527 vs SAE1 — BRCA

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