Spinal cord association neuron differentiation

Across TCGA cell cohorts, RNA activity of the Spinal cord association neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC16, PPP1R12B, and MED30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC16 grouped by Spinal cord association neuron differentiation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	H2AC16 →	-1.415	-1.854	.001	.008	3	4
STOMACH	PPP1R12B →	-0.966	-1.263	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	MED30 →	-1.104	-1.609	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	COX6C →	-1.245	-2.213	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PFDN6 →	-0.851	-1.621	.007	<.001	3	3
LUNG_SCLC	UBE2G2 →	+0.574	+0.958	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC16 by Spinal cord association neuron differentiation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →