Spinal cord motor neuron differentiation

pathway activity — cross-omics
GO:0021522Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Spinal cord motor neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WRNIP1_S65, LUZP1_S1042, and ATP5MF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVWRNIP1_S65 →-1.508-0.887<.001<.00124
OVLUZP1_S1042 →+0.691+0.866<.001<.00133
OVATP5MF →-0.799-0.707.001<.00133
OVSCYL1_S754 →+0.784+0.726<.001<.00133
OVYEATS2_S447 →-1.013-0.781<.001<.00133
OVCDC5L →-0.224-0.792<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration