Spinal cord motor neuron differentiation

Across TCGA cell cohorts, RNA activity of the Spinal cord motor neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC56, RND3, and CIAPIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC56 grouped by Spinal cord motor neuron differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRRC56 →	+1.105	+1.904	<.001	<.001	3	4
LIVER	RND3 →	-1.370	-1.827	<.001	<.001	2	4
LIVER	CIAPIN1 →	+0.548	+1.145	.002	.003	3	3
SOFT_TISSUE	ERRFI1 →	-2.598	-1.197	.004	<.001	3	3
SOFT_TISSUE	ACVR1B →	-0.788	-1.584	<.001	<.001	3	3
SOFT_TISSUE	SLC8A1 →	-3.381	-1.216	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC56 by Spinal cord motor neuron differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →