Ventral spinal cord development

Across TCGA patient cohorts, RNA activity of the Ventral spinal cord development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK3, PLEKHO2, and SEC24A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventral spinal cord development activity versus DOK3 in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOK3 →	-0.414	-0.044	.004	<.001	3	7
BRCA	PLEKHO2 →	-0.261	-0.026	.009	.004	3	7
BRCA	SEC24A →	-0.294	-0.040	<.001	<.001	3	6
GBM	TYMP →	-0.376	-0.030	.007	.002	3	6
GBM	FMNL1 →	-0.603	-0.047	<.001	<.001	3	6
GBM	FYB1 →	-0.624	-0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021517 vs DOK3 — GBM

Explore this scatter interactively →