Ventral spinal cord development

Across TCGA cell cohorts, RNA activity of the Ventral spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLX4IP, RSPH1, and PSMA6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventral spinal cord development activity versus SLX4IP in LUNG_SCLC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLX4IP →	+0.649	+1.058	<.001	.003	3	3
LUNG_SCLC	RSPH1 →	+2.229	+1.597	.001	.003	3	2
BLOOD_Leukemia	PSMA6 →	-2.269	-1.664	.002	.005	2	3
LUNG_SCLC	NOMO1 →	-0.761	-1.300	.009	.007	3	2
LUNG_SCLC	TMEM159 →	-2.442	-1.475	.007	.001	3	2
BLOOD_Leukemia	CHD6 →	+0.559	+1.511	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021517 vs SLX4IP — LUNG_SCLC

Explore this scatter interactively →