Dorsal spinal cord development

Across TCGA cell cohorts, RNA activity of the Dorsal spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN16, CLSTN1, and TMEM265, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN16 grouped by Dorsal spinal cord development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLDN16 →	-0.614	-0.765	.002	.005	3	4
UPPER_AERODIGESTIVE_TRACT	CLSTN1 →	-0.924	-1.026	<.001	.003	3	4
STOMACH	TMEM265 →	-2.841	-1.376	.006	.004	3	4
BLOOD_Lymphoma	AKAP11 →	-1.324	-1.805	.006	<.001	3	4
URINARY_TRACT	RWDD3 →	-0.665	-1.509	.005	<.001	3	4
URINARY_TRACT	FAM111A →	-1.013	-1.505	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN16 by Dorsal spinal cord development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →