Dorsal spinal cord development

Across TCGA pan-cancer cohorts, RNA activity of the Dorsal spinal cord development pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher Dorsal spinal cord development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and STAD, show the opposite pattern, with higher activity associated with better survival.

ESCA, READ, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.818	0.571	<.001	64	view →
READ	OS	Tertile	III,IV	0.738	0.974	.001	52	view →
UCEC	DFS	Median	All	0.532	0.744	.001	50	view →
SCLC	OS	Median	All	0.565	0.824	<.001	50	view →
COAD	DFS	Quartile	All	0.591	0.806	<.001	42	view →
STAD	DFS	Quartile	All	0.769	0.577	.013	21	view →
KIRC	DFS	Median	All	0.867	0.722	<.001	21	view →
LUAD	DFS	Median	II,III,IV	0.752	0.538	.002	21	view →
PAAD	DFS	Tertile	All	0.421	0.196	.008	18	view →
OV	DFS	Tertile	III,IV	0.206	0.128	.011	18	view →
LAML	DFS	Quartile	All	0.440	0.667	.022	14	view →
LGG	OS	Median	All	0.862	0.925	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0021516–ESCA (OS)

Open the ESCA breakdown →