Cell differentiation in spinal cord

Across TCGA cell cohorts, RNA activity of the Cell differentiation in spinal cord pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS4, COBLL1, and GPR22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAUS4 grouped by Cell differentiation in spinal cord-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HAUS4 →	-0.723	-1.068	.003	<.001	3	4
SOFT_TISSUE	COBLL1 →	-2.242	-1.254	<.001	.009	3	4
LIVER	GPR22 →	+0.042	+1.213	.001	.003	3	3
LUNG_NSCLC_LUAD	SNX31 →	-0.048	-0.776	.003	.003	3	3
URINARY_TRACT	RPL13A →	-0.821	-1.533	.003	<.001	3	3
OVARY	PGD →	-0.686	-1.177	.005	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HAUS4 by Cell differentiation in spinal cord activity — CNS

Explore this box plot interactively →