Spinal cord development

Across TCGA patient cohorts, RNA activity of the Spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRC2B, ZNF512B, and BCORL1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord development activity versus PRRC2B in CHOL (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	PRRC2B →	+1.335	+0.038	<.001	<.001	3	31
SCLC	ZNF512B →	+0.992	+0.091	<.001	<.001	3	31
TGCT	BCORL1 →	+1.133	+0.037	<.001	<.001	3	31
CHOL	ZC3H7B →	+0.934	+0.044	<.001	<.001	3	31
MESO	KAT6B →	+0.954	+0.029	<.001	<.001	3	30
SCLC	ASXL1 →	+0.825	+0.078	.001	.004	2	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021510 vs PRRC2B — CHOL

Explore this scatter interactively →