Spinal cord development

Across TCGA pan-cancer cohorts, RNA activity of the Spinal cord development pathway is associated with patient survival in 15 of 34 cancer lineages. Pathway activity is summarized from the expression of its 102 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Spinal cord development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and UVM, show the opposite pattern, with higher activity associated with better survival.

COAD, ESCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.721	0.830	.001	51	view →
ESCA	OS	Median	II,III,IV	0.677	0.436	.002	27	view →
UVM	OS	Median	II,III,IV	0.890	0.403	.001	21	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
READ	DFS	Median	III,IV	0.578	0.799	.021	14	view →
THYM	DFS	Tertile	II,III,IV	0.605	1.000	.006	12	view →
KIRC	DFS	Tertile	IV	0.251	0.623	.025	12	view →
LIHC	OS	Tertile	III,IV	0.318	0.820	.003	12	view →
CESC	DFS	Median	All	0.771	0.863	.002	10	view →
GBM	DFS	Median	All	0.371	0.208	.030	6	view →
KICH	OS	Tertile	III,IV	0.178	0.814	.014	6	view →
THCA	DFS	Tertile	All	0.926	0.686	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GO:0021510–COAD (DFS)

Open the COAD breakdown →