Spinal cord development

Across TCGA patient cohorts, RNA activity of the Spinal cord development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBX1, THEMIS2_T593, and RNF213, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord development activity versus PBX1 in HNSC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PBX1 →	+0.619	+0.043	<.001	<.001	3	8
LSCC	THEMIS2_T593 →	-0.817	-0.047	<.001	<.001	3	7
CCRCC	RNF213 →	-0.344	-0.059	<.001	<.001	3	7
LSCC	C15orf48 →	-0.607	-0.028	<.001	.002	3	7
GBM	CRLF3 →	-0.312	-0.035	<.001	.001	3	7
LSCC	FYB1 →	-0.739	-0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021510 vs PBX1 — HNSC

Explore this scatter interactively →