Spinal cord development

Across TCGA patient cohorts, RNA activity of the Spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GZMB, IL21, and CXCR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord development activity versus GZMB in OV (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GZMB →	-1.103	-0.790	.001	.006	2	5
UCEC	IL21 →	-0.425	-0.654	.004	<.001	3	4
LUAD	CXCR3 →	-0.397	-0.286	.004	.005	3	4
LUAD	SLAMF7 →	-0.517	-0.347	.002	<.001	3	4
LUAD	CCL5 →	-1.010	-0.598	<.001	<.001	3	4
BRCA	LINC01871 →	-0.819	-0.459	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021510 vs GZMB — OV

Explore this scatter interactively →